| 22. Runde | ||||||||
|---|---|---|---|---|---|---|---|---|
| 03.05.2021 | 18:30 | Paços de Ferreira | Paços de Ferreira | - | Nasjonal CD | Nasjonal CD | -: - | |
| 03.05.2021 | 20:45 | Sporting CP | Sporting CP | - | CD Santa Clara | CD Santa Clara | -: - | |
| 03/06/2021 | 15:30 | Portimonense SC | Portimonense SC | - | CD Tondela | CD Tondela | -: - | |
| 03/06/2021 | 18:00 | Gil Vicente | Gil Vicente | - | FC Porto | FC Porto | -: - | |
| 03/06/2021 | 20:30 | God utsikt | God utsikt | - | FC Famalicão | FC Famalicão | -: - | |
| 03/07/2021 | 17:30 | CS Maritime | CS Maritime | - | Moreirense FC | Moreirense FC | -: - | |
| 03/07/2021 | 20:00 | Rio Ave FC | Rio Ave FC | - | SC Farense | SC Farense | -: - | |
| 03.08.2021 | 20:15 | Belenenses | Belenenses | - | SL Benfica | SL Benfica | -: - | |
| 03/09/2021 | 21:45 | Sportslige Braga | Sportslige Braga | - | Vitória Guimarães | Vitória Guimarães | -: - | |
| 23. Runde | ||||||||
| 03/12/2021 | 20:30 | Nasjonal CD | Nasjonal CD | - | CS Maritime | CS Maritime | -: - | |
| 03/13/2021 | 15:30 | SC Farense | SC Farense | - | Belenenses | Belenenses | -: - | |
| 03/13/2021 | 18:00 | CD Santa Clara | CD Santa Clara | - | Portimonense SC | Portimonense SC | -: - | |
| 03/13/2021 | 20:30 | CD Tondela | CD Tondela | - | Sporting CP | Sporting CP | -: - | |
| 03/14/2021 | 15:00 | Moreirense FC | Moreirense FC | - | Rio Ave FC | Rio Ave FC | -: - | |
| 03/14/2021 | 17:30 | Vitória Guimarães | Vitória Guimarães | - | Gil Vicente | Gil Vicente | -: - | |
| 03/14/2021 | 18:00 | SL Benfica | SL Benfica | - | God utsikt | God utsikt | -: - | |
| 03/14/2021 | 20:00 | FC Porto | FC Porto | - | Paços de Ferreira | Paços de Ferreira | -: - | |
| 15.03.2021 | 20:15 | FC Famalicão | FC Famalicão | - | Sportslige Braga | Sportslige Braga | -: - |
| | | |
Overføringer
| 02/21 | Jean-Clair Todibo | Jean-Clair Todibo | SL Benfica | SL Benfica | | OGC Hyggelig | OGC Hyggelig |
| 10/20 | Marko Grujic | Marko Grujic | Liverpool FC | Liverpool FC | | FC Porto | FC Porto |
| 10/20 | Felipe Anderson | Felipe Anderson | West Ham United | West Ham United | | FC Porto | FC Porto |
| 10/20 | Malang Sarr | Malang Sarr | Chelsea FC | Chelsea FC | | FC Porto | FC Porto |
| 10/20 | Tiago Dantas | Tiago Dantas | SL Benfica | SL Benfica | | Bayern München II | Bayern München II |
| 10/20 | Alex Such | Alex Such | FC Porto | FC Porto | | Manchester United | Manchester United |
| 10/20 | Hvem | Hvem | SL Benfica | SL Benfica | | Ekte Valladolid | Ekte Valladolid |
| 07/21 | Danilo | Danilo | Paris Saint Germain | Paris Saint Germain | | FC Porto | FC Porto |
| 10/20 | Thomas Tavares | Thomas Tavares | SL Benfica | SL Benfica | | CD Alaves | CD Alaves |
| 10/20 | Carlos Vinícius | Carlos Vinícius | SL Benfica | SL Benfica | | Tottenham Hotspur | Tottenham Hotspur |
